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目的:观察硫酸镁联合硝苯地平治疗子痫前期患者的血压改善状况及妊娠结局。方法:选取62例子痫前期患者的资料进行回顾性研究,按治疗方案不同分为对照组和观察组。观察组32例采用硫酸镁联合硝苯地平治疗,对照组30例采用硫酸镁治疗。比较两组患者治疗前后血压变化,以及两组临床疗效、妊娠并发症及妊娠结局。结果:治疗后,两组患者收缩压与舒张压均较治疗前明显降低(P<0.05),且观察组患者血压明显低于对照组(P<0.05)。观察组临床总有效率为96.88%,明显高于对照组的73.33%(P<0.05)。观察组宫缩乏力、产后出血、胎儿宫内窘迫、胎盘早剥的发生率明显低于对照组(P<0.05),剖宫产率、新生儿窒息率也均明显低于对照组(P<0.05)。结论:硫酸镁联合硝苯地平治疗子痫前期患者,降压效果明显,能降低妊娠并发症的发生率、减少不良妊娠结局的发生,疗效优于单纯硫酸镁治疗。
Objective: To observe the improvement of blood pressure and pregnancy outcome in patients with preeclampsia treated with magnesium sulfate and nifedipine. Methods: The data of 62 cases of preeclampsia were selected retrospectively and divided into control group and observation group according to different treatment regimen. 32 cases in the observation group were treated with magnesium sulfate and nifedipine, and 30 cases in the control group were treated with magnesium sulfate. The changes of blood pressure before and after treatment were compared between the two groups, as well as the clinical efficacy, pregnancy complications and pregnancy outcome in the two groups. Results: After treatment, systolic pressure and diastolic pressure were significantly decreased in both groups (P <0.05), and the blood pressure in the observation group was significantly lower than that in the control group (P <0.05). The total effective rate of the observation group was 96.88%, which was significantly higher than that of the control group (73.33%, P <0.05). The incidence of uterine inertia, postpartum hemorrhage, fetal distress and placental abruption in observation group were significantly lower than those in control group (P <0.05), cesarean section rate and neonatal asphyxia rate were also significantly lower than those in control group (P < 0.05). Conclusion: Magnesium sulfate combined with nifedipine in the treatment of patients with preeclampsia, antihypertensive effect is obvious, can reduce the incidence of pregnancy complications, reduce the incidence of adverse pregnancy outcomes, the effect is better than the simple magnesium sulfate treatment.