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目的观察幽门螺杆菌(Hp)感染及血清白细胞介素8(IL-8)与初发脑梗死的关系,探讨IL-8在Hp感染可能导致脑梗死机制中的作用。方法80例初发脑梗死(观察组),其中动脉粥样硬化性血栓性脑梗死49例(A组),腔隙性脑梗死31例(B组)。采用病例对照1∶1配对的研究方式选择对照,检测观察组和对照组血清标本的Hp特异性抗体IgG(Hp-IgG)、IL-8、C-反应蛋白(CRP)浓度等。结果观察组Hp-IgG阳性率为81%,对照组为58%,二者比较差异有统计学意义(P<0.01);A组Hp-IgG阳性率为88%,对照组为55%,二者比较差异有统计学意义(P<0.01);B组Hp-IgG阳性率为71%,对照组为61%,二者比较差异无统计学意义(P=0.41)。观察组的IL-8浓度高于对照组(P<0.01),IL-8浓度与Hp-IgG浓度、与CRP浓度、临床神经功能缺损程度分数正相关(P值均<0.01)。结论Hp感染与动脉粥样硬化性脑梗死发病相关;脑梗死发病后血清IL-8浓度升高,并且与Hp-IgG浓度、CRP浓度、临床神经功能缺损程度评分正相关。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection, serum interleukin-8 (IL-8) and primary cerebral infarction and to explore the role of IL-8 in the pathogenesis of Hp infection. Methods 80 cases of primary cerebral infarction (observation group), including 49 cases of atherothrombotic cerebral infarction (group A), 31 cases of lacunar infarction (group B). Hp-specific IgG (Hp-IgG), IL-8 and C-reactive protein (CRP) concentrations in the serum samples of the observation group and the control group were selected by the case control 1: 1 paired study. Results The positive rate of Hp-IgG in observation group was 81% and in control group was 58%, the difference was statistically significant (P <0.01). The positive rate of Hp-IgG in group A was 88% and that in control group was 55% (P <0.01). The positive rate of Hp-IgG in group B was 71% and that in control group was 61%. There was no significant difference between the two groups (P = 0.41). The concentrations of IL-8 and Hp-IgG in the observation group were significantly higher than those in the control group (P <0.01). The concentrations of IL-8 and Hp-IgG in the observation group were positively correlated with the CRP concentration and the degree of clinical neurological deficit (P <0.01). Conclusions Hp infection is associated with the pathogenesis of atherosclerotic cerebral infarction. The concentration of serum IL-8 is increased after the onset of cerebral infarction, and positively correlated with the Hp-IgG concentration, CRP concentration and clinical neurological deficit score.