目的探讨肾素血管紧张素原(angiotensinogen,AGT)M235T基因多态性与脑白质疏松症(Leukoaraiosis,LA)的相关性。方法采用聚合酶链反应(PCR)及聚合酶链反应-限制片段长度多态性(PCR-RFLP)及Sequenom系统检测,经头部MRI确诊的202例脑白质疏松症患者及105例经MRI排除LA的正常对照者AGTM235T基因多态性。结果脑白质疏松症患者AGTMT基因型及T等位基因频率与对照组有明显差异,两组间TT基因型差异无统计学意义。结论 AGT基因MT基因型和T等位基因可能与脑白质疏松症的发病相关。 Objective To investigate the association between M235T gene polymorphism of angiotensinogen (AGT) and leukoaraiosis (LA). Methods PCR-RFLP and Sequenom PCR were used to detect 202 cases of leukoaraiosis who were diagnosed by head MRI and 105 cases were excluded by MRI AGTM235T gene polymorphism in normal controls of LA. Results The frequencies of AGTMT genotypes and T allele in patients with leukoaraiosis were significantly different from those in control group. There was no significant difference in TT genotype between the two groups. Conclusion MT genotype and T allele of AGT gene may be related to the pathogenesis of leukoaraiosis.