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目的:评价伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎的临床疗效。方法 :将59例重度慢性牙周炎患者随机分为对照治疗组(n=29)和干预治疗组(n=30)。对所有患者进行口腔卫生指导、龈上洁治和抛光。龈上洁治后1周内,干预治疗组口服伐昔洛韦,对照治疗组口服安慰剂。2组患者均在龈上洁治1周后,于48 h内分2次完成龈下刮治和根面平整。在基线点以及牙周治疗后2、6个月时对所有患者进行牙周检查。采用SPSS17.0软件包对数据进行统计学分析。结果:在基线时,对照治疗组与干预治疗组间牙周指标的差异均无显著性。治疗后2个月和6个月,干预治疗组探诊出血(bleeding on probing,BOP)阳性位点百分比减少值、牙周探诊深度(probing depth,PD)≥4 mm的位点百分比减少值和PD的减少值均显著高于对照治疗组(P<0.05),干预治疗组临床附着水平(clinical attachment level,CAL)的减少值与对照治疗组比较虽有所升高,但差异无显著性。结论:应用伐昔洛韦作为重度慢性牙周炎机械治疗的辅助治疗,可显著提高临床疗效。
OBJECTIVE: To evaluate the clinical efficacy of valacyclovir combined with subgingival scaling and root planing in the treatment of severe chronic periodontitis. Methods: 59 patients with chronic severe periodontitis were randomly divided into control group (n = 29) and intervention group (n = 30). Oral hygiene instrumentation, supragingival scaling, and polishing for all patients. Within 1 week after supraginggorism, the intervention group received oral valacyclovir, and the placebo was given to the control group. After 2 weeks, the patients in both groups were treated with subgingival scaling and root-surface formation in 2 h after subgingival scaling for 1 week. All patients underwent periodontal examinations at baseline and at 2,6 months after periodontal treatment. SPSS17.0 software package for statistical analysis of the data. RESULTS: At baseline, there was no significant difference in periodontal index between control and intervention groups. At 2 months and 6 months after treatment, the percentage of reduction in the percentage of positive sites of bleeding on probing (BOP) and the percentage reduction of sites of probing depth (PD) ≥ 4 mm And PD decreased significantly (P <0.05). The decrease of clinical attachment level (CAL) in intervention group was higher than that in control group, but there was no significant difference . Conclusion: The application of valacyclovir as adjuvant therapy for severe chronic periodontitis can significantly improve the clinical efficacy.