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目的:比较正常妊娠与病理妊娠胎盘滋养细胞Fas L的表达,从免疫学角度分析病理妊娠的可能发病机制。方法:采用免疫组织化学SP法检测96例病理妊娠患者胎盘组织中FasL的表达,通过高清晰彩色病理免疫组化测量系统对其定量分析,取52例正常孕妇胎盘作对照进行比较。结果:病理妊娠组中妊娠高血压综合征(妊高征)、胎儿窘迫、早产3组患者胎盘滋养细胞表面FasL表达面积明显低于正常组(P<0.01),且3组胎盘滋养细胞表面FasL表达强度(包括平均光度及积分光度)也明显低于正常组(P<0.01),但3组间差异无显著意义(P>0.05)。结论:妊高征、胎儿窘迫、早产的胎盘绒毛发育不全、功能下降等一系列的免疫病理改变可能与胎盘滋养细胞表面FasL表达减少有关。
Objective: To compare the expression of Fas L in normal pregnancy and placental trophoblast of pathological pregnancy and to analyze the possible pathogenesis of pathological pregnancy from the perspective of immunology. Methods: Immunohistochemical SP method was used to detect the expression of FasL in placental tissue of 96 patients with pathological pregnancy. Quantitative analysis was performed by high-resolution colorimetric immunohistochemistry. 52 normal pregnant women were compared with each other. Results: The area of FasL expression on placental trophoblast cells in patients with gestational hypertension (PIH), fetal distress and preterm birth in pathological pregnancy group was significantly lower than that in normal group (P <0.01), and the expression of FasL on placental trophoblast The expression intensity (including mean luminosity and integral luminosity) was also significantly lower than that of the normal group (P <0.01), but there was no significant difference among the three groups (P> 0.05). CONCLUSION: A series of immunopathological changes such as PIH, fetal distress, premature placenta hypoplasia and decreased function may be related to the decrease of FasL expression on the surface of placental trophoblast cells.