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目的:探讨急性缺血性脑卒中患者血清超敏C-反应蛋白(hs-CRP)的水平对卒中后功能障碍的预测价值。方法:分别在发病后第1和7天,采用颗粒增强免疫透射比浊法对92例急性缺血性脑卒中患者检测血清hs-CRP水平,并选取40例健康受试者作为对照。随访并记录患者1月、3月和6月mRS评分。结果:①急性缺血性脑卒中患者血清hs-CRP水平较对照组显著升高。②急性缺血性卒中患者入院1d和7d血清hs-CRP水平与1月、3月和6月mRS评分,均有明显的相关性。与入院1d血清hs-CRP水平相比,入院7d血清hs-CRP水平与mRS评分相关性更好。③与无颈动脉粥样硬化危险因素的缺血性卒中患者相比,有颈动脉粥样硬化危险因素的缺血性卒中患者入院7d血清hs-CRP水平明显升高。结论:与入院1d血清hs-CRP水平相比,入院7d血清hs-CRP水平对卒中后功能障碍的预测价值更好。
Objective: To investigate the predictive value of serum hs-CRP levels in patients with acute ischemic stroke after stroke. Methods: Serum hs-CRP levels were measured in 92 patients with acute ischemic stroke by particle-enhanced immunoturbidimetry on day 1 and day 7, respectively. Forty healthy subjects were selected as controls. Patients were followed up and recorded mRS scores in January, March and June. Results: ① The level of hs-CRP in acute ischemic stroke patients was significantly higher than that in control group. ② The serum hs-CRP levels at 1 and 7 days after hospital admission in acute ischemic stroke patients were significantly correlated with the mRS scores in January, March and June. Compared with the level of hs-CRP on admission 1d, the level of hs-CRP on admission 7d was more correlated with the mRS score. ③ Serum hs-CRP levels in patients with ischemic stroke at risk of carotid atherosclerosis were significantly higher at 7 days after hospital admission compared with ischemic stroke patients without risk of carotid atherosclerosis. CONCLUSION: Compared with the serum hs-CRP level at 1 day after admission, the serum hs-CRP level at 7 days after admission is more predictive for post-stroke dysfunction.