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应用~(57)Co和~(58)Co分别标记内因子结合态和游离态维生素B_(12)吸收试验,检测了萎缩性胃炎74例,胃手术后13例,回肠切除术后1例,晚期血吸虫病10例和正常人6例,其中31例恶性贫血呈维生素B_(12)吸收障碍,有15例仅示~(58)Co吸收低下,16例则示~(57)Co和~(58)Co均吸收不良,各为10.5±6.2％和4.22±2.78％(正常人为23.1±1.21％和24.1±2.66％);4例全胃切除者~(58)Co吸收严重障碍(0.08±0.15％),而6例血清维生素B_(12)水平低下的胃大部切除后病人维生素B_(12)吸收正常。另同时检测血清维生索B_(12)和内因子浓度、内因子抗体,据此分析和讨论了各种因素和维生素B_(12)吸收障碍的关系。
Indomethacin and free vitamin B 12 (12) absorption test were performed by using ~ (57) Co and ~ (58) Co respectively, and 74 patients with atrophic gastritis, 13 patients after gastric surgery, 1 patient after ileal resection, Schistosomiasis in 10 cases and normal in 6 cases, of which 31 cases of pernicious anemia showed vitamin B 12 (12) absorption disorders, 15 cases showed only ~ (58) Co absorption was low, 16 cases showed ~ 57 Co and ~ 58 ) Co had poor malabsorption of 10.5 ± 6.2% and 4.22 ± 2.78% respectively (normal subjects were 23.1 ± 1.21% and 24.1 ± 2.66%); ), While 6 cases of patients with low level of serum vitamin B_ (12) had normal absorption of vitamin B 12 after subtotal gastrectomy. At the same time, serum B12 (12), internal factor concentration and internal factor antibody were also detected, and the relationship between various factors and vitamin B 12 (12) absorption disorder was analyzed and discussed.