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SAPHO综合征是一种独立的疾病，以滑膜炎、痤疮、脓疱病、骨肥厚和骨髓炎的不同组合为表现，是一种罕见的以皮肤和关节的明显炎症为表现的疾病。本病患者中存在TH17的活化，而非TH1和TH2。本病患者外周血中TH17增加，与其它单基因自身炎症性疾病（AID）患者表现相似。慢性复发性多灶性骨髓炎是一种相关的AID，起病一般在儿童期。本文对SAPHO患者使用生物制剂的文献进行回顾，同时简单报告了在临床上使用生物制剂治疗SAPHO综合征的经验。“,”SAPHO syndrome is an independent disease, characterized for synovial inflammation, acne, impetigo, hyperostosis, and osteomyelitis different combination. It is a rare disease, the main performance as inflammation of the skin and joints. Patients was TH17 activation, rather than the TH1 and TH2. Patients was increased with TH17 in Peripheral blood, and was similar of patients with single gene autoinflammatory disease (AID). Chronic recurrent multifocal osteomyelitis is a relevant AID, usually in childhood onset. This article reviewed the SAPHO patients treatment it using biological agents, and simple reported the experience for treatment of SAPHO syndrome using biological agents in clinical.