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局部应用氟化物(包括氟溶液漱口、牙面涂氟、含氟牙膏刷牙等)预防龋齿虽已有数十年历史,然至今对其机制仍缺乏圆满的解释,同时临床上防龋效果的报告也不尽一致。为了最大限度地增加局部用氟防龋的临床效果和安全性,国内外学者在氟化物的选择和使用条件的选择方面作了大量研究,普遍将釉质吸氟量作为衡量用氟效果的一项重要指标。一些研究分别表明,局部用氟时氟溶液的浓度、pH值和温度,均可能影响釉质吸氟量,而釉质吸氟量的多少又与氟的防龋效果有关。本实验在临床上可行的氟化钠浓度、溶液pH值和温度范围内各选择四个点,以正交试验法组合氟处理时的溶液条件,同时观察氟溶液浓度、pH值和温度对牙釉质体外吸收氟的影响,为深入了解釉质吸氟量与防龋效果的关系提供线索。
Topical application of fluoride (including fluoride solution mouthwash, fluoride toothpaste, fluoride toothpaste brushing, etc.) to prevent dental caries Although decades of history, so far the mechanism is still lack of satisfactory explanation, while the clinical effect of anti-caries The report is also not consistent. In order to maximize the clinical efficacy and safety of topical fluorocarbon anti-caries, scholars at home and abroad have done a lot of research on the selection of fluorides and the conditions for their use. Generally speaking, enamel fluoride uptake as a measure of fluoride effect Important indicators. Some studies have shown that fluoride concentration in the topical fluoride solution, pH and temperature may affect the enamel fluoride absorption, while the amount of enamel fluoride absorption and fluoride anti-caries effect. This experiment in the clinical feasible sodium fluoride concentration, pH value and temperature range of the choice of four points to orthogonal test method combined with fluoride solution conditions, while observing the concentration of fluorine solution, pH and temperature on the teeth Enamel absorption of fluoride in vitro, in order to understand the relationship between enamel fluoride absorption and the effect of anti-caries provide clues.