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目的探讨CD36单核苷酸多态性(SNPs)与老年动脉粥样硬化性脑梗死(ACI)相关性。方法选取75岁以上ACI患者121例作为病例组,对照组选取无脑梗死病史体检者217例。采用PCR-LDR技术检测CD36rs1761667、rs9784998两个位点基因型,ELISA法测定血栓素B2。结果病例组rs9784998基因型、等位基因频率与对照组相比无统计学差异(P>0.05)。rs1761667 AG基因型频率分布在两组间具有统计学差异(χ2=7.03,P<0.01)。Logistic多因素分析和逐步回归分析显示,与其他两种基因型相比,AG基因型均能增加脑梗死的患病风险(P<0.05)。病例组血栓素B2水平较对照组明显升高(P<0.01),但AG基因型人群中血栓素B2水平两组间无统计学差异(P>0.05)。结论 CD36 rs9784998单核苷酸多态性与动脉粥样硬化性脑梗死无统计学相关,rs1761667单核苷酸多态性是老年动脉粥样硬化性脑梗死的遗传危险因素。CD36基因多态性与血栓素B2无统计学相关。
Objective To investigate the association between single nucleotide polymorphisms (SNPs) of CD36 and aged atherosclerotic cerebral infarction (ACI). Methods A total of 121 ACI patients over 75 years old were selected as the case group and 217 healthy control subjects without cerebral infarction. The genotypes of CD36 rs1761667 and rs9784998 were detected by PCR-LDR and thromboxane B2 was detected by ELISA. Results There was no significant difference in rs9784998 genotype and allele frequencies between the two groups (P> 0.05). rs1761667 AG genotype frequency distribution between the two groups was statistically significant (χ2 = 7.03, P <0.01). Logistic multivariate analysis and stepwise regression analysis showed that AG genotype increased the risk of cerebral infarction compared with the other two genotypes (P <0.05). Thromboxane B2 level was significantly higher in the case group than in the control group (P <0.01), but there was no significant difference between the two groups in AG genotype (P> 0.05). Conclusion There is no significant correlation between single nucleotide polymorphisms of CD36 rs9784998 and atherosclerotic cerebral infarction. Rs1761667 SNP is a genetic risk factor of senile atherosclerotic cerebral infarction. CD36 gene polymorphism and thromboxane B2 no statistical correlation.