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目的:探讨吸烟对亚临床甲减患者颈动脉粥样硬化的影响。方法:选取63例亚临床甲减男性患者,分为吸烟组33例和非吸烟组30例,并选取同期来本院体检的46例健康男性为对照组。检测所有受试者的血脂水平和颈动脉内膜中层厚度(IMT),并对各组结果进行比较分析。结果:非吸烟组、吸烟组的血浆TG、TC、LDLC、颈动脉IMT均高于对照组(均P<0.01),吸烟组的血浆TG、TC、LDL-C、颈动脉IMT高于非吸烟组(均P<0.05);非吸烟组、吸烟组的血浆HDL-C均低于对照组(均P<0.01),吸烟组的血浆HDL-C低于非吸烟组(P<0.05)。结论:吸烟可加重亚临床甲减患者的血脂异常和颈动脉粥样硬化程度,应尽早进行临床干预。
Objective: To investigate the effect of smoking on carotid atherosclerosis in subclinical hypothyroidism. Methods: Sixty-three patients with subclinical hypothyroidism were enrolled and divided into smoking group (33 cases) and non-smoking group (n = 30). 46 healthy men who took physical examination at the same period were selected as the control group. All subjects were tested for lipid levels and carotid intima-media thickness (IMT), and the results of each group were compared. Results: TG, TC, LDLC and carotid artery IMT in non-smoking group and smoking group were significantly higher than those in control group (all P <0.01). Plasma TG, TC, LDL-C and carotid IMT in smoking group were higher than those in non-smoking group HDL-C in non-smoking group and smoking group were lower than those in control group (all P <0.01). HDL-C in smoking group was lower than that in non-smoking group (P <0.05). Conclusion: Smoking can aggravate the degree of dyslipidemia and carotid atherosclerosis in subclinical hypothyroidism patients. Clinical intervention should be carried out as early as possible.