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目的:氟西汀与西沙比利联用治疗社区功能性消化不良患者的临床疗效。方法:选取2013年9月—2015年1月间接受治疗的功能性消化不良患者138例,按照数字随机表法将其分为常规组和联用组,每组69例,常规组患者均给予西沙比利治疗,联用组患者均给予氟西汀与西沙比利联用治疗,比较两组患者治疗后的总有效率。结果:治疗2月后,联用组患者治疗的总有效率为79.71%明显优于常规组为92.75%(P<0.05);两组患者临床症状经汉密尔顿抑郁量表(HAMD)评分,其评分值联用组患者优于常规组(P<0.05);治疗6月后随访,联用组患者复发率低于常规组(P<0.05)。结论:氟西汀与西沙比利联用治疗功能性消化不良患者的临床疗效果优于单用西沙比利治疗,能够有效改善患者的临床症状,降低了疾病的复发率,提升患者的生活质量。
Objective: The clinical efficacy of fluoxetine combined with cisapride in the treatment of community functional dyspepsia patients. Methods: A total of 138 patients with functional dyspepsia who received treatment between September 2013 and January 2015 were selected. According to the digital random table method, they were divided into routine group and combined group, with 69 cases in each group. Cisapride treatment, the combination group patients were given fluoxetine and cisapride combination therapy, the two groups were compared after the treatment of the total efficiency. Results: After 2 months of treatment, the total effective rate of treatment group was 79.71%, which was significantly higher than that of the control group (92.75%) (P <0.05). The clinical symptoms of the two groups were evaluated by Hamilton Depression Rating Scale (HAMD) Patients in combined therapy group were superior to conventional therapy group (P <0.05). After 6 months of follow-up treatment, the recurrence rate of combined therapy group was lower than that of conventional therapy group (P <0.05). Conclusions: Fluoxetine and cisapride combined with cisapride in patients with functional dyspepsia is superior to the single treatment with cisapride, which can effectively improve the clinical symptoms, reduce the recurrence rate and improve the quality of life of patients .