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应用ELISA(夹心法)测定了Graves病(GD),甲低(PH),桥本氏甲腺炎(HT)等自身免甲状腺疾病患者的SIL-2R水平,并对反映患者甲状腺功能的各种甲状腺相关激素水平以及甲状腺自身抗体的相关性进行了比较。结果表明:GD患者(28例)血清SIL-2R水平为2001.33±400.14U/ml,显著高于正常对照组(31例,415.3±331.23U/ml,P<0.001)。PH患者(16例)sIL-2R测定值为523.59±404.73U/ml和正常人相比较无显著性差异(P<0.05)。除TSH外sIL-2R和多种甲状腺相关激素水平正相关,尤以T3,FT3最为密切相关(n=93 r=0.88 P<0.001)。sIL-2R和甲状腺自身抗体TGAb,TMAb,TSI滴度也显著相关(P<0.001)。
The levels of SIL-2R in Graves’ disease (GD), hypothyroidism (PH), Hashimoto’s thyroiditis (HT) and other thyroid-free thyroid diseases were measured by ELISA (sandwich method) Thyroid-related hormone levels and thyroid autoantibodies were compared. The results showed that the serum levels of SIL-2R in GD patients (2001) were 2001.33 ± 400.14U / ml, significantly higher than those in the normal controls (31 cases, 415.3 ± 331.23U / ml, P <0.001). The measured value of sIL-2R in PH patients (16 cases) was 523.59 ± 404.73U / ml and there was no significant difference (P <0.05) compared with normal subjects. In addition to TSH, sIL-2R was positively correlated with various thyroid-related hormone levels, especially T3 and FT3 (n = 93 r = 0.88 P <0.001). There was also a significant correlation between sIL-2R and thyroid autoantibodies TGAb, TMAb and TSI titers (P <0.001).