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目的观察前列地尔联合小牛血去蛋白提取物治疗糖尿病足效果。方法选取该院科室在2015年8月—2016年8月接诊的64例糖尿病足患者,在征得患者及其家属的通后,按照抽签的方式将64例患者平均分成实验组(32例)和对照组(32例)。实验组患者给予前列地尔联合小牛血去蛋白提取物的治疗,对照组给予常规治疗(西洛他唑、维生素B_1,和甲基维生索B_(12))。对比两组患者在治疗前后的血糖、总胆固醇、甘油三酯和血流变等指标的变化。结果实验组患者和对照组患者在治疗前后的血糖、总胆固醇、甘油三酯均有所下降,差异有统计学意义(P<0.05),治疗后实验组和对照组间血脂和血流变指标对比差异有统计学意义(P<0.05),血糖指标对比差异无统计学意义(P>0.05)。结论前列地尔联合小牛血去蛋白提取物治疗糖尿病足效果好于常规治疗效果,建议在临床推广使用。
Objective To observe the effects of alprostadil combined with deproteinized calf blood extract on diabetic foot. Methods Sixty-four patients with diabetic foot admitted to our hospital from August 2015 to August 2016 were selected and randomly divided into experimental group (32 cases ) And control group (32 cases). Patients in the experimental group were treated with alprostadil combined with bovine deproteinized extract, while those in the control group were given conventional treatment (cilostazol, vitamin B_1, and methylthio-B 12). The changes of blood glucose, total cholesterol, triglyceride and blood rheology in two groups before and after treatment were compared. Results The blood glucose, total cholesterol and triglyceride in experimental group and control group decreased before and after treatment (P <0.05). After treatment, the levels of blood lipid and blood rheology in experimental group and control group were significantly lower than those in control group There was significant difference between the two groups (P <0.05). There was no significant difference between the two groups (P> 0.05). Conclusion The combination of alprostadil and deproteinized calf blood extract is better than the conventional treatment in the treatment of diabetic foot, which is recommended for clinical use.