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开玛是计算机辅助即时监测给药系统的简称，它可维持药物效应在预定水平。根据药理效应和同时记录进入体内的药量，开玛可以揭示机体的反应性。22只出血性休克家兔给予0.01％间羟胺3h使血压维持在休克前水平。根据间羟胺药量和血压变化，家兔表现出3种不同类型：下降型、上升型和迟钝型。下降型和上升型动物血压都能维持在预定水平，但间羟胺的剂量却分别表现为逐渐下降或上升，而迟钝型的血压即使以最大速度恒速灌注也不能升到预定值。血乳酸浓度的测定说明间羟胺对每种类型的治疗效果是不同的。开玛系统揭示的失血性休克家兔对间羟胺的个体差异性，这是其它方法难以做到的。
Kaima is an abbreviation for computer-assisted real-time monitoring of drug delivery system, which can maintain the drug effect at a predetermined level. According to pharmacological effects and at the same time record the amount of drug into the body, open the Mary can reveal the body’s reactivity. Twenty-two hemorrhagic shock rabbits were given 0.01% meta-hydroxylamine 3h to maintain blood pressure at pre-shock level. According to the amount of meta-hydroxylamine and blood pressure changes, the rabbit showed three different types: descending, ascending and dull. The blood pressure of both descending and ascending animals can be maintained at a predetermined level, but the dose of metahydroxylamine appears to be gradually decreased or increased, while the dull type of blood pressure can not rise to the predetermined value even when perfused at a constant speed at a maximum speed. The measurement of blood lactate concentration shows that meta-hydroxylamine is different for each type of treatment. The difference between the individual hydroxylamine in hemorrhagic shock rabbits revealed by Kaimai system is difficult to achieve by other methods.