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体外实验观察低分子右旋糖酐(DX40)、甘露醇、丹参及藻酸双酯钠(PSS)对红细胞悬浮液粘弹特性的影响。结果显示:随着药物浓度增加,甘露醇能使η_(5·96)、η_(51·2)、η′、η″和G′增高;DX40使η′、η″和G′值升高,对η_(5·96)、η_(51·2)的影响均不明显;而丹参及PSS对η_(5·96)、η_(51·2)、η′、η″和G′影响均不明显,但丹参及PSS组的η′、η″和G′的平均值都低于DX40和甘露醇组的相应值。由此表明在治疗剂量时该4种药物有助于改善血液粘弹性。用于治疗缺血性脑血管疾病以及其他高血粘综合症时,丹参注射液和PSS输入速度可快一些,但甘露醇和DX40的输入速度不能过快。
The effects of low molecular dextran (DX40), mannitol, Salvia miltiorrhiza and sodium alginate (PSS) on viscoelastic properties of red blood cell suspensions were observed in vitro. The results showed that mannitol increased η_(5·96), η_(51·2), η′, η′′ and G′ as the drug concentration increased; DX40 increased η′, η′′ and G′ The effects of η_(5·96) and η_(51·2) are not obvious; while the effects of Salviae Miltiorrhizae and PSS on η_(5·96), η_(51·2), η′, η′′ and G′ However, the average values of η′, η′′, and G′ in the Danshen and PSS groups were lower than those in the DX40 and mannitol groups. This shows that the 4 drugs help to improve the blood viscoelasticity at the therapeutic dose. For the treatment of ischemic cerebrovascular disease and other hyperviscosity syndromes, the input speed of Danshen injection and PSS can be faster, but the input speed of mannitol and DX40 should not be too fast.