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血管紧张素(angiotensin,Ang)-(1-7)是肾素-血管紧张素系统中除AngⅡ以外,另一种重要的调节肽,主要作用于Mas受体发挥作用。Ang-(1-7)通过与其Mas受体的结合,发挥血管扩张和抗细胞增殖等作用,抗衡AngⅡ与其AT1受体结合产生的血管收缩、血压升高、细胞增殖、尿钠潴留等作用。近年来研究发现,Ang-(1-7)及其Mas受体在局部组织生理功能中具有积极作用,在多种疾病病理过程中具有保护作用。
Angiotensin (Ang) - (1-7) is another important regulatory peptide besides Ang II in renin-angiotensin system and mainly acts on Mas receptors. Ang- (1-7) exerts its functions of vasodilation and anti-cell proliferation by binding with its Mas receptor and antagonizes the vasoconstriction, blood pressure, cell proliferation and urine retention caused by the binding of AngII to its AT1 receptor. In recent years, it has been found that Ang- (1-7) and its Mas receptor have a positive effect on local tissue physiological functions and have protective effects on various pathological processes.