有机硝酸酯（organicnitrate，ONT）在急性心肌缺血综合征——不稳定性心绞痛和急性心肌梗死中应用已逾百年。传统概念中，ONT主要临床药理机理为松弛血管平滑肌，扩张冠状动脉，减轻心脏容量及压力负荷，减少心肌耗氧，达到缓解心肌缺血性胸痛，限制急性心肌梗死范围扩大，增 Organic nitrates (ONTs) have been used in acute myocardial ischemia syndromes - unstable angina and acute myocardial infarction for more than a century. The traditional concept of ONT main pharmacological mechanism for the relaxation of vascular smooth muscle, coronary artery expansion, reduce cardiac capacity and pressure load, reduce myocardial oxygen consumption, to alleviate myocardial ischemic chest pain, limiting the scope of the expansion of acute myocardial infarction, increased