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分析16例生存期超过7年的慢性粒细胞白血病(CML)患者,发现长期存活与确诊时外周血原粒+早幼粒细胞、嗜碱粒细胞及骨髓中原粒+早幼粒细胞比例有关,而与确诊时肝脾大小、外周血血红蛋白、白细胞、血小板高低及骨髓中巨核细胞数关系不大。长期存活与首次缓解期长短呈正相关。对16例发生过骨髓抑制的患者观察说明,骨髓抑制通常不能延长生存期,有可能促使急性变的发生。对9例CML伴骨髓纤维化的分析表明,骨髓纤维化是CML进入加速期的表现之一。
Analysis of 16 patients with chronic myeloid leukemia (CML) with a survival of more than 7 years showed that long-term survival was related to the ratio of protoplasm + promyelocytic, basophilic and myeloid progenitor cells in peripheral blood at the time of diagnosis. And with the diagnosis of liver and spleen size, peripheral blood hemoglobin, white blood cells, platelet levels and the number of megakaryocytes in the bone marrow does not matter. Long-term survival and the length of the first remission was positively correlated. The observation of 16 patients with myelosuppression showed that myelosuppression usually can not prolong survival and may lead to acute change. Nine cases of CML with myelofibrosis analysis showed that bone marrow fibrosis is one of the manifestations of CML into accelerated phase.