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目的:综述加替沙星引起的各种不良反应,为临床用药提供参考。方法:利用数据库检索和收集临床资料,兼顾少见不良反应病例报道进行系统性综述。结果:140份临床研究资料共有8095个临床使用加替沙星的病例参加安全性评价,发生不良反应病人数为653个(8.07%),计789例次(9.75%);不良反应涉及消化系统、神经系统、心血管系统及皮肤等多个系统和器官,其中以消化系统反应为主,其次为神经系统;口服给药的不良反应平均发生率为7.51%,静脉滴注给药的不良反应平均发生率为8.26%,序贯给药方法的不良反应平均发生率为10.26%。结论:加替沙星的不良反应发生率为8.07%;口服给药低于注射给药。加替沙星引起血糖紊乱等少见严重不良反应必须引起临床的高度重视。
Objective: To summarize various adverse reactions caused by gatifloxacin and provide references for clinical use. Methods: A systematic review was carried out using database retrieval and clinical data collection, taking into account the reports of rare adverse reactions. Results: A total of 8095 clinically used cases of gatifloxacin in 140 clinical trials participated in the safety evaluation. The number of adverse reactions was 653 (8.07%), accounting for 789 cases (9.75%). The adverse reactions involved digestive system , Nervous system, cardiovascular system and skin and many other systems and organs, of which the digestive system reaction, followed by the nervous system; the average incidence of adverse reactions of oral administration was 7.51%, intravenous infusion of adverse reactions The average incidence rate was 8.26%. The average rate of adverse reactions was 10.26% in sequential administration. Conclusion: The incidence of adverse reactions of gatifloxacin was 8.07%. Oral administration was lower than that of injection. Gatifloxacin caused by blood glucose disorders and other rare serious adverse reactions must arouse clinical attention.