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将34例缺血性心脏病或心肌病所致的慢性充血性心衰患者分为1组(19例)使用袢利尿剂和2组(15例)联用袢利尿剂和血管紧张素转换酶抑制剂(ACEI)。研究前至少规则服药三个月。肾功不全(血肌酐>120μmol/L及干扰肾脏镁潴留的因素如酒精中毒,吸收障碍和含镁化合物的摄入)均不纳入研究。为减少病人体内基础镁浓度的差异性,均给予硫酸镁负荷量(500ml葡萄糖中镁30μmol静滴8小时以上),分别测定24小时尿中镁及肌酐的浓度。结果发现两组病人(年龄,体重,利尿剂使用量均相似)血镁浓度均在正常范围且数值相接近。24小时镁的排泄在ACEI组明显降低,两组的镁清除率无显著性差异。
Thirty-four patients with chronic congestive heart failure due to ischemic heart disease or cardiomyopathy were divided into one group (n = 19) with diuretics and two groups (n = 15) with diuretics and angiotensin converting enzyme Inhibitor (ACEI). At least three months prior to study medication. Renal insufficiency (serum creatinine> 120 μmol / L and factors that interfere with renal magnesium retention, such as alcoholism, malabsorption, and intake of magnesium-containing compounds) were excluded from the study. In order to reduce the difference of the basic magnesium concentration in the patients, the magnesium sulfate load (500 microliters of glucose and 30 micromol of glucose for more than 8 hours) was given and the concentrations of magnesium and creatinine in the urine were measured at 24 hours. The results showed that two groups of patients (age, weight, diuretic use were similar) serum magnesium concentrations are in the normal range and the values are close. 24 hours of magnesium excretion was significantly reduced in the ACEI group, no significant difference between the two groups of magnesium clearance.