慢性粒细胞白血病为一多能干细胞受损的克隆性疾病,其终末期可表现不同类型的急变。但慢粒并何杰金氏病为罕见,现将我院收治1例报告如下。患者,女,32岁,因头昏,疲乏伴纳差1年余入院。体检:中度贫血外貌,皮肤粘膜无出血点及紫癜,浅表淋巴结不肿大,胸骨无压痛,心肺(一),脾大:脐下1cm,右侧超过正中线1.5(?)m,胸片,心电图、胃十二指肠钡餐及肝功能检查均(一),血清铁蛋白16ug%,AFP<10mμg/ml,血 Hb:64g/l,WBC 134400×10~9/L,早幼粒3%,中幼粒4%,晚幼粒1(?)%,杆状37%,分叶17%,淋巴10%,嗜酸细胞5%,嗜硷细胞6%,血小板146×10~9/L,骨髓像呈慢性粒细胞白血病改变。有核细胞增生极度活跃,粒:红=37.6:1,原粒1%,早幼粒3%,中幻粒14%,晚幼 Chronic myeloid leukemia is a clonal disease of impaired pluripotent stem cells, whose terminal stage can manifest different types of abrupt changes. But Cochlear and Hodgkin’s disease is rare, now in our hospital admitted to a report as follows. Patients, female, 32 years old, due to dizziness, fatigue, with anorexia more than 1 year admitted to hospital. Physical examination: moderate anemia appearance, skin and mucous membrane without bleeding point and purpura, superficial lymph nodes are not enlarged, sternum no tenderness, cardiopulmonary (a), splenomegaly: 1cm below the umbilicus, right side of the midline 1.5 (?) M, chest Electrocardiogram, gastroduodenal barium meal and liver function tests (a), serum ferritin 16ug%, AFP <10mμg / ml, blood Hb: 64g / l, WBC 134400 × 10 ~ 9 / L, promyelocytic 3%, 4% of juvenile grains, 1 (?)% Of late juveniles, 37% of stems, 17% of lobes, 10% of lymphomas, 5% of eosinophils, 6% of basophils and 146 × 10 ~ 9 of platelets / L, bone marrow showed chronic myeloid leukemia changes. Nucleated cell hyperplasia extremely active, grain: red = 37.6: 1, the original grain 1%, promyelocytic 3%, phantom 14%, late child