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目的探讨AFP、CEA、GPC3联合检测用于原发性肝癌诊断的临床效果。方法选取在湖南省肿瘤医院进行检测的原发性肝癌患者53例作为A组、肝硬化患者61例作为B组,健康体检者123例作为C组,比较三组血清AFP、CEA、GPC3水平。结果三者联合检测的敏感度为96.23%,特异度为58.70%,符合率为67.09%,相对于单独检测差异有统计学意义(P<0.05),A组血清AFP、CEA、GPC3水平显著高于B组和C组,差异有统计学意义(P<0.05)。结论血清AFP、CEA、GPC3水平用于原发性肝癌的诊断具有一定的价值,三者联合检测可明显提高诊断的敏感度,但特异度和符合率均降低。因此,临床应用时应综合考虑,合理评估。
Objective To investigate the clinical effect of combined detection of AFP, CEA and GPC3 in the diagnosis of primary liver cancer. Methods Totally 53 primary hepatocellular carcinoma patients diagnosed in Hunan Cancer Hospital were selected as Group A, 61 patients with cirrhosis as Group B and 123 healthy subjects as Group C. The serum levels of AFP, CEA and GPC3 were compared among the three groups. Results The sensitivity, specificity and accuracy of the three methods were 96.23%, 58.70% and 67.09%, respectively, which were significantly higher than those of the other two groups (P <0.05). The serum AFP, CEA and GPC3 levels in group A were significantly higher In group B and group C, the difference was statistically significant (P <0.05). Conclusions Serum AFP, CEA and GPC3 levels are of value in the diagnosis of primary liver cancer. The combination of the three tests can significantly improve the diagnostic sensitivity, but the specificity and coincidence rate are all lower. Therefore, the clinical application should be considered, a reasonable assessment.