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合成了三(邻甲基苄基)锡硫代水杨酸酯配合物(1)和一维链状二(间氟苄基)锡硫代水杨酸酯配合物(2),经元素分析、IR、NMR、X射线衍射等技术手段表征了其结构。配合物1属三斜晶系,空间群Pī,晶体学参数a=1.00221(5)nm,b=1.48934(8)nm,c=1.71789(9)nm,α=78.3120(10)°,β=85.6560(10)°,γ=80.2580(10)°,V=2.4725(2)nm~3,Z=2,Dc=1.371 g/cm~3,μ(Mo Kα)=10.91 cm~(-1),F(000)=1040,R_1=0.0439,wR_2=0.1119。配合物2属单斜晶系,空间群为P21/n,晶体学参数:a=1.17827(5)nm,b=2.11945(9)nm,c=1.55970(7)nm,β=93.4510(10)°,V=3.8880(3)nm~3,Z=4,Dc=1.671 g/cm~3,μ(Mo Kα)=14.53 cm~(-1),F(000)=1936,R1=0.0323,wR2=0.0927。配合物1中锡原子呈四配位畸变四面体构型,配合物2中锡原子呈五配位畸变三角双锥构型。配合物1和2分别在152和195℃下稳定,电化学性质不可逆,对人体癌细胞Colo205、Hep G2、MCF-7、Hela和NCI-H460具有体外抗癌活性,配合物2的抗癌活性远大于配合物1。
Synthesis of tris (o-methylbenzyl) tin thiosalicylate complex (1) and 1D chain bis (m-fluorobenzyl) tin thiosalicylate complex (2) , IR, NMR, X-ray diffraction and other technical means to characterize the structure. The complex 1 belongs to the triclinic system with space group Pī. The crystallographic parameters a = 1.00221 (5) nm, b = 1.48934 (8) nm, c = 1.71789 (9) nm and α = 78.3120 85.6560 (10) °, γ = 80.2580 (10) °, V = 2.4725 (2) nm ~ 3, Z = 2, Dc = 1.371 g / cm ~ 3 and μ (Mo Kα) = 10.91 cm -1. , F (000) = 1040, R_1 = 0.0439, wR_2 = 0.1119. The complex 2 belongs to the monoclinic system with a space group of P21 / n. The crystallographic parameters are as follows: a = 1.17827 (5) nm, b = 2.11945 (9) nm, c = 1.55970 (V) = 3.8880 (3) nm ~ 3, Z = 4, Dc = 1.671 g / cm ~ 3 and μ (Mo Kα) = 14.53 cm -1, F (000) = 1936, wR2 = 0.0927. In the complex 1, the tin atom showed tetrahedrally distorted tetrahedral configuration, and the tin atom in the complex 2 showed a five-coordinate distorted triangular double cone configuration. Complexes 1 and 2 were stable at 152 and 195 ℃, respectively, and their electrochemical properties were not reversible. The antitumor activity of complex 2 against human cancer cells Colo205, Hep G2, MCF-7, Hela and NCI-H460 was tested in vitro. Much larger than complex 1.