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目的检测前列腺特异性膜抗原(PSMA)及人质膜型唾液酸酶(hmSD或Neu3)在前列腺癌组织中的表达。方法收集30例前列腺癌患者(A组)及35例前列腺增生患者(B组)手术切除的组织,采用半定量RT-PCR方法检测PSMA及hmSD表达。结果 PSMA在A和B组表达阳性率分别为86.7%(26/30)和68.6%(24/35)(P>0.05);A组PSMA mRNA表达量明显高于B组(P<0.05)。A组hmSD表达阳性率明显高于B组(90.0%vs.57.1%)(P<0.05);A组hmSD mRNA表达量明显高于B组(P<0.05)。结论 PSMA及hmSD在前列腺癌组织中的表达高于前列腺增生组织。
Objective To detect the expression of prostate-specific membrane antigen (PSMA) and human plasma membrane-type sialidase (hmSD or Neu3) in prostate cancer. Methods Thirty patients with prostate cancer (group A) and 35 patients with benign prostatic hyperplasia (group B) underwent surgical resection. The expression of PSMA and hmSD were detected by semi-quantitative RT-PCR. Results The positive rates of PSMA in group A and B were 86.7% (26/30) and 68.6% (24/35) respectively (P> 0.05). The expression of PSMA mRNA in group A was significantly higher than that in group B (P <0.05). The positive rate of hmSD in group A was significantly higher than that in group B (90.0% vs.57.1%, P <0.05). The expression of hmSD mRNA in group A was significantly higher than that in group B (P <0.05). Conclusion The expression of PSMA and hmSD in prostate cancer tissues is higher than that in benign prostatic hyperplasia tissues.