观察ＨＤＶ／ＨＢＶ同时和重叠两种感染树■所致实验性丁型肝炎肝脏病理变化。方法树■ＨＢＶ．ＨＤＶ阳性血清按同时和重叠两种方式静脉接种，感染后一周起每周剖腹取肝活组织一次，连续１２周。肝组织以１０％中性福尔马林固定，石蜡包埋切片，ＨＥ染色，光镜观察（参照１９９０年上海全国肝炎会议制定的病理标推）。确定ＨＤＶ感染的指标以在树■血清或在肝切片上检出ＨＤＶ标志。结果１０例同时感染树■肝脏全有病毒性肝炎样病变，第一周即见到有程度不等的气球样变性、点状或灶性坏死，炎细胞浸润。以后发展不一，３例自愈，１例呈急性重型。６例进展为慢性。５例重叠感染树■，在单纯ＨＢＶ感染时，肝脏病变轻；重叠ＨＤＶ后，病变都有明显进展，均形成慢性，３例为慢性迁延性肝炎，２例慢性活动性肝炎。结论树■感染ＨＤＶ后致丁型肝炎的肝脏病变与人类极为相似；可呈现不同的病理类型，易形成慢性发病过程。 Observe the simultaneous and overlapping HDV / HBV infection of two infected trees ■ Experimental hepatic pathological changes in hepatitis. Method Tree ■ HBV. HDV-positive sera were inoculated intravenously in two simultaneous and overlapping ways. One week after infection, liver biopsies were taken once a week for 12 consecutive weeks. Liver tissue was fixed in 10% neutral formalin, embedded in paraffin, stained with HE and observed with light microscope (refer to the pathological standard set by Shanghai National Hepatitis Conference in 1990). Indicators of HDV infection were determined to detect HDV markers on tree serum or on liver sections. Results 10 cases of simultaneous infection of the tree ■ liver all have viral hepatitis-like lesions, the first week to see varying degrees of balloon degeneration, punctate or focal necrosis, inflammatory cell infiltration. After the development of different, 3 cases of self-healing, 1 was acute heavy. 6 cases progressed to chronic. In 5 cases of overlapping infection, the hepatic lesions were mild in the case of HBV infection. After the overlap of HDV, the lesions were significantly advanced, both of them were chronic, 3 cases were chronic persistent hepatitis and 2 cases were chronic active hepatitis. Conclusions Tree ■ Hepatic lesions causing hepatitis D after HDV infection are very similar to those in humans; they may present different pathological types and may develop a chronic disease.