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研制由女性自主使用的、兼具避孕和抗生殖道感染双重功能的外用避孕药已成为国际发展趋势和热点。目前国内外有一系列的候选药物正处于不同的研发阶段,其中,醌类和马来酰亚胺类化合物具有作为双功能外用避孕药的研发潜质,为该领域的研究工作带来新的突破点,但仍面临很多挑战,亟需建立剂型研究、生殖道黏膜免疫炎症反应评价、药物动力学研究以及生殖道微生态评价等关键技术。
The development of topical contraceptives, which are independently used by women and have the dual functions of contraception and anti-genital infection, has become an international trend and hotspot. At present, a series of candidate drugs at home and abroad are in different stages of research and development. Among them, quinones and maleimides have the potential to be developed as dual-function topical contraceptives and bring new breakthroughs in the field of research , But still face many challenges, there is an urgent need to establish key technologies such as formulation research, mucosal immune inflammation reaction of the reproductive tract, pharmacokinetic studies, and microbiological evaluation of genital tract.