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55例不同颅内压的亚急性1,2-二氯乙烷(1,2-DCE)中毒患者分为颅内压升高组(A组,26例)和颅内压正常组(B组,29例),比较两组患者临床表现、头颅CT变化特点以及病程、转归等情况。A组患者头痛头晕、恶心呕吐及意识障碍的发生率分别高于B组(P<0.01),临床表现恶化时间晚于B组(t=4.59,P<0.01),而临床表现好转和恢复的时间则早于B组(t=-2.49,P<0.05);但A组病死率高,起病隐匿,容易造成误诊。颅内压监测对于1,2-DCE引起的亚急性中毒性脑病病情判断及预后有着重要意义,头颅CT可以作为筛查手段,有助于早期发现、早期施行有针对性治疗,从而降低死亡率,提高治愈率。
Fifty-five patients with sub-acute 1,2-dichloroethane (1,2-DCE) poisoning with different intracranial pressure were divided into intracranial hypertension group (group A, n = 26) and normal intracranial pressure group (group B , 29 cases). The clinical manifestations, changes of head CT, course of disease and outcome were compared between the two groups. The incidence of headache dizziness, nausea, vomiting and disturbance of consciousness in group A were significantly higher than those in group B (P <0.01), and the clinical manifestations were delayed later than in group B (t = 4.59, P <0.01) The time was earlier than that in group B (t = -2.49, P <0.05). However, the mortality in group A was high, and the onset of occult disease was easily concealed. Intracranial pressure monitoring for 1,2-DCE-induced subacute toxic encephalopathy in the judgment and prognosis of great significance, head CT can be used as a screening tool to help early detection, early implementation of targeted treatment, thereby reducing mortality , Improve the cure rate.