【摘 要】
：
A method using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester(BSA/NHS) as coupling agents for dipeptide synthesis is descried. The coupling reactio
【机 构】
：
Department of New Drug Research and Development,Institute of Materia Medica & Peking Union Medical C
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
A method using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester(BSA/NHS) as coupling agents for dipeptide synthesis is descried. The coupling reaction between N-hydroxysuccinimide(NHS)esters and amines could be performed under mild conditions with N,O-bis(trimethylsilyl)acetamide(BSA) as coupling reagent and no additional acid/base is required. All byproducts and excessive reactants are water soluble or hydrolysable and easy to eliminate through water-washing at the purification stage.Moreover, all the reactants are inexpensive and widely used in conventional drug production.
A method using N, O-bis (trimethylsilyl) acetamide / N-hydroxysuccinimide ester (BSA / NHS) as coupling agents for dipeptide synthesis is descried. The coupling reaction between N-hydroxysuccinimide (NHS) All byproducts and excessive reactants are water soluble or hydrolysable and easy to eliminate through water-washing at the purification stage. Corevay, all the reactants are inexpensive and widely used in conventional drug production.
其他文献
自 1 999～ 2 0 0 0年我院抢救 4例重症河豚鱼中毒体会报告如下。1 临床资料例 1 ,男 ,5 4岁 ,食用河豚鱼 1小时后头昏 ,并出现恶心、呕吐。于 1 999年 1 2月 2 2日 2小时后转
近日在迪拜国际展览中心举行的2012年沙特国际建筑建材博览会上,华菱星马汽车集团以强大产品阵容参展,全面展现了其高端重卡和成熟专用汽车的品牌形象。
Recently held at t
孤独症的环境因素与遗传因素同等重要孤独症,又称为自闭症,是一种神经系统失调导致的发育障碍,表现为早期不能进行正常的语言表达和社交活动,并且常见做一些刻板、重复性和限
4月11日,中国汽车工业协会发布了3月产销数据。当月,商用车销售43.86万辆,同比下降8.8%。1～3月,商用车销售101.9万辆,同比下降10.6%。在市场整体低迷的大环境里,东风公司以3月
小张夫妇结婚九年才喜得千金。小两口看着可爱的女儿,一切烦恼、忧愁均烟消云外,乐得合不拢嘴。小宝宝取名为美美。她可真乖,只有在饥饿或大小便时才报警式地小哭几下。小张
本文采用固相反应方法制备了一系列YBa2Cu3O7-δ(Y123)+0.25molY2O3+x wt%BaCeO3(x=0.0,2.0,5.0,10.0and 20.0)多晶样品,通过X射线衍射法(XRD)和扫描电子显微镜(SEM)对Y2O3和
庆尚南道(韩国省级行政区)位于朝鲜半岛东南端,面积11566平方公里,约占韩国国土总面积的11.6％。其北与庆尚北道相连,西隔小白山脉与蟾津江和全罗北道为邻,东部和南部临海。境
In this paper, ultrafine nitrogen-doped TiO_2 photocatalyst with enhanced photocatalytic water-splitting properties was successfully fabricated via a solvotherm
1990年初夏,在古城小巷旧书摊获见旧摺扇一件,扇骨佚缺不全,书扇中间有蛀洞四处,幸未殃及背面画作。据摊主称一面是名画家樊少云的字,另一面不知画家是谁。你若喜欢,可便宜些
古玩城扩大营业面积,经营明清硬木家具的百年老店——萃文斋进驻古玩城。 李文斋内宽敞、明亮,屋内摆满了古香古色的硬木家具,桌案、凳椅、床榻、橱柜……此外,还陈设
Anti