论文部分内容阅读
目的研究黄体酮-平阳霉素乳剂与聚乙烯醇微粒在子宫肌瘤介入治疗中的临床疗效及不良反应。方法随机将86例子宫肌瘤患者分为聚乙烯醇微粒组和黄体酮-平阳霉素乳剂栓塞组。采用Seldinger技术,经皮穿刺行双侧子宫动脉插管,注入聚乙烯醇微粒或黄体酮-平阳霉素乳剂阻断子宫肌瘤血供。记录治疗后患者月经量情况,并于治疗前后用B超测量子宫肌瘤体积。结果两组患者月经量恢复正常率间差别无显著性意义(P>0·05);两组患者术后3个月、6个月时肌瘤体积间差别均无显著性意义(P>0·05)。术后发热及缺血性盆腔疼痛为两组的主要不良反应,均无严重并发症。结论使用黄体酮-平阳霉素乳剂栓塞子宫动脉治疗子宫肌瘤的疗效与聚乙烯醇颗粒相当,但其副作用较少,且该栓塞剂价格较低。
Objective To study the clinical efficacy and adverse reactions of progesterone-pingyangmycin emulsion and polyvinyl alcohol particles in interventional therapy of uterine fibroids. Methods Totally 86 cases of uterine fibroids were divided into polyvinyl alcohol granules group and progesterone-pingyangmycin emulsion embolization group. Using Seldinger technique, percutaneous puncture bilateral uterine artery catheterization, injection of polyvinyl alcohol particles or progesterone - pingyangmycin emulsion block uterine fibroids blood supply. Record the patient’s menstrual flow after treatment, and measure the volume of uterine fibroids with B-ultrasound before and after treatment. Results There was no significant difference in normal menstruation between the two groups (P> 0.05). There was no significant difference in the volume of fibroids between the two groups at 3 months and 6 months after operation (P> 0 · 05). Postoperative fever and ischemic pelvic pain were the main adverse reactions in both groups, with no serious complications. Conclusions The efficacy of embolization of uterine artery with progesterone - pingyangmycin emulsion in the treatment of uterine fibroids is comparable to that of polyvinyl alcohol particles with less side effects and lower price of the embolic agent.