The possibility of 5He cluster emission has been affirmed theoretically. In order to describe the emission probability of 5He cluster, the pre-formation probability of 5He cluster in pre-equilibrium emission process is needed to be established. In terms of Iwamoto-Harada model, the theoretical formula of pre-formation probability of 5He cluster including 1p shell nucleon in pre-equilibrium mechanism has been established and calculated. In the case of low incident energies, the configuration of [1, m] for 5He cluster is the dominant part in the nuclear reaction. The calculated results indicate that pre-formation probability of configuration [1, m] for the unstable 5He cluster is much smaller than those of d, t, 3He, and 4He, i.e. the light stable composite particles, which are consisted of only 1s shell nucleons. However, it is propitious to the emission of 5He from the point of view on threshold energies, since the binding energies of 5He are generally lower than that of 3He in compound nucleus. The corresponding model formula has been given in this paper for described pre-formation probability of 5He cluster in pre-equilibrium mechanism.