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亲环素A(cyclophilinA,CyPA)是一种胞质蛋白,属于亲免素家族(Cyclophilins)成员。它广泛存在并且大量表达于各种组织中,高度保守,具有肽脯氨酰顺反异构酶活性,能够参与多种信号转导途径。亲环素A具有很多生物学功能,包括血管疾病和免疫调节、肿瘤发生等。本文就CyclophilinA蛋白在心脑血管疾病中的研究进展进行综述。
Cyclophilin A (CyPA) is a cytoplasmic protein that belongs to the family of Cyclophilins. It is widely present and abundantly expressed in various tissues, highly conserved, and has peptide prolyl cis-trans isomerase activity and is capable of participating in various signal transduction pathways. Cyclophilin A has many biological functions, including vascular diseases and immune regulation, tumorigenesis and so on. This article reviews the research progress of Cyclophilin A in cardiovascular and cerebrovascular diseases.