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目的：观察丹参酮IIA磺酸钠注射液（STS）治疗晚期血吸虫病（晚血）临床效果。方法选择2012-011-2013-11入住东台市头灶中心卫生院的晚血患者50例，予以STS治疗10 d，治疗前、后进行门静脉内径、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶（γ-GT）、Ⅲ型前胶原肽、Ⅳ型胶原、层黏蛋白、透明质酸（HA）检测。结果治疗前血清学检测指标的均值除HA高于正常外，余均正常；指标异常患者数最高分别为γ-GT（26.0%）及HA（54.0%）。治疗后各项指标均值和指标异常患者数均有所下降，但HA的均值仍高于正常。门静脉内径由治前的（10.5±1.7）mm降至治后的（9.8±1.3） mm，改善明显。结论 STS对晚血病人的治疗具有一定的效果，适合于基层单位使用。“,”Objective To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate(STS)in the treatment of ad-vanced schistosomiasis. Methods Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dong-tai City during the period from November 2012 to November 2013 were treated with STS for 10 days,and the internal diameter of the portal vein,levels of ALT,AST,γ-GT,PIIIP,CIV,HA and LN were measured and compared before and after the adminis-tration of STS. Results The mean levels of all serological parameters except HA were within the normal range before STS treat-ment,while the highest positive rate was detected inγ-GT(26.0%)and HA(54.0%). Following the STS treatment,the mean lev-els of all parameters and the positive rates reduced,with the greatest reduction observed inγ-GT(36.7%)and HA(37.8%);how-ever,the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from(10.5± 1.7)mm before the STS treatment to(9.8±1.3)mm after the STS administration,with a significant diffrtence(P<0.05). Conclu-sion STS appears effective in the treatment of advanced schistosomiasis.