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目的:观察纳洛酮联合复方丹参注射液治疗急性酒精中毒临床效果。方法:81例急性酒精重度患者,随机分为2组。对照组41例,单纯使用纳洛酮治疗;观察组40例,在对照组治疗基础上加用复方丹参注射液治疗。观察格拉斯哥昏迷评分(GCS)并比较2组患者清醒时间、各时间段内起效人数以及不良反应等指标。结果:2组GCS评分治疗前后比较,差异均有统计学意义(P<0.01),治疗后观察组的GCS评分较对照组更高,2组比较,差异有统计学意义(P<0.01)。观察组清醒时间及症状消失时间较对照组短,2组比较,差异有统计学意义(P<0.01)。2 h内清醒人数观察组较对照组多,2组比较,差异有统计学意义(P<0.01);4 h、6 h清醒人数与对照组比较,差异有统计学意义(P<0.05)。恶心呕吐、心悸、口舌干燥等不良反应,观察组较对照组少,2组比较,差异有统计学意义(P<0.05)。结论:复方丹参注射液联合纳洛酮对急性酒精重度效果显著,患者清醒时间快,且不良反应发生率低。
Objective: To observe the clinical effect of Naloxone and Fufang Danshen injection in the treatment of acute alcoholism. Methods: A total of 81 acute alcoholic patients were randomly divided into two groups. Control group of 41 cases, simple use of naloxone treatment; observation group of 40 patients in the control group based on the treatment with compound Salvia injection. Glasgow Coma Scale (GCS) was observed and the awake time, the number of onset of effect in each time period and the adverse reactions were compared. Results: The GCS scores of the two groups were significantly higher than those of the control group before and after treatment (P <0.01). The difference between the two groups was statistically significant (P <0.01). The awake time and the disappearance of symptoms in the observation group were shorter than those in the control group. The differences between the two groups were statistically significant (P <0.01). The awakened number of observation group within 2 h was more than that of the control group. The difference between the two groups was statistically significant (P <0.01). The awake number of 4 h and 6 h was significantly different from that of the control group (P <0.05). Nausea and vomiting, heart palpitations, dry mouth and other adverse reactions, the observation group than the control group, the two groups, the difference was statistically significant (P <0.05). Conclusion: The compound salvia miltiorrhiza injection combined with naloxone has significant effect on acute alcohol, the patients wake up fast, and the incidence of adverse reactions is low.