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目的:为了解垂体腺瘤的雌、孕激素受体分布情况及临床意义。方法:采用免疫组化方法检测了60例手术治疗的垂体腺瘤的雌激素受体(ER)、孕激素受体(PR),并结合内分泌功能分类和临床影像学检查进行研究。结果:研究表明,垂体腺瘤ER阳性率为77％,PR阳性率为67％。大的巨腺瘤ER、PR阳性率低于微腺瘤(PR间x~2=8.158,P=0.017<0.05)。细胞生长活跃的腺瘤ER、PR常阴性。不同功能类型的垂体腺瘤ER、PR阳性率亦不同。结论:研究提示ER、PR与垂体腺瘤的分化侵袭有关,ER、PR检测可能是垂体腺瘤选择治疗和评估预后的一项指标。
Objective: To understand the distribution of estrogen and progesterone receptors in pituitary adenoma and its clinical significance. Methods: The estrogen receptor (ER) and progesterone receptor (PR) in 60 surgically-treated pituitary adenomas were detected by immunohistochemistry and combined with endocrine function classification and clinical imaging examination. Results: The study showed that pituitary adenoma ER positive rate was 77%, PR positive rate was 67%. The positive rate of ER and PR in large giant adenomas was lower than that of microadenomas (PR x = 2 = 8.158, P = 0.017 <0.05). Active adenoma cells ER, PR often negative. Different types of pituitary adenomas ER, PR positive rate is also different. CONCLUSION: The results suggest that ER and PR are involved in the differentiation and invasion of pituitary adenomas. The detection of ER and PR may be an indicator of choice treatment and prognosis of pituitary adenomas.