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目的探讨膳食因素与血浆高敏C反应蛋白(hs CRP)水平的关系。方法以志愿者的形式招募广州市40~65岁居民,采用膳食频数问卷法(FFQ)调查研究对象的膳食摄入情况,并用免疫比浊散射法检测其血浆hs CRP的水平。结果共招募553名志愿者,血浆hs CRP值为(1.56±2.19)mg/L。校正了年龄、教育程度、吸烟、饮酒、BMI、能量摄入等混杂因素的偏相关分析显示,女性的蔬菜、水果摄入量与hs CRP水平负相关(P<0.05),总体研究对象碳水化合物、膳食纤维的摄入量与hs CRP负相关(P<0.05),在男性中膳食纤维的相关关系显著(P<0.05)。根据血浆hs CRP水平<1 mg/L、1~3 mg/L、≥3 mg/L预测可能发生心血管疾病(CVD)的低、中、高风险,在校正了年龄、性别、BMI等混杂因素后,Logistic回归分析显示:随着水果摄入量、膳食纤维摄入量的减少、研究对象将来发生高hs CRP的风险增加(P<0.05);以最高摄入量Q4组为对照,水果摄入量Q3组、膳食纤维摄入量Q2组、脂肪供能比Q1组、饱和脂肪酸供能比Q2组是Q4组将来发生高hs CRP的风险的1.69、1.71、0.42、0.41倍(OR值)(P<0.05)。结论增加膳食中蔬菜、水果、碳水化合物、膳食纤维的摄入可降低血浆hs CRP水平,增加水果和膳食纤维摄入量、控制膳食总脂肪供能比、降低饱和脂肪供能比可能会降低心血管疾病发生的风险。
Objective To investigate the relationship between dietary factors and plasma high-sensitivity C-reactive protein (hs CRP) levels. Methods Residents of 40-65 years old were enrolled in Guangzhou as volunteers. Dietary frequency questionnaire (FFQ) was used to investigate the dietary intake of subjects. Plasma hs CRP levels were measured by immunoturbidimetric scattering. Results A total of 553 volunteers were enrolled. The plasma hs CRP value was (1.56 ± 2.19) mg / L. Partial correlation analysis of confounding factors such as age, education level, smoking, alcohol consumption, BMI and energy intake showed that there was a negative correlation between vegetable and fruit intake of women and hs CRP level (P <0.05). The overall study object carbohydrate , Dietary fiber intake was negatively correlated with hs CRP (P <0.05), and there was a significant correlation between dietary fiber and male dietary fiber (P <0.05). The low, medium and high risk of cardiovascular disease (CVD) was predicted based on the plasma levels of hs CRP <1 mg / L, 1-3 mg / L, and ≥3 mg / L. Age, gender, Logistic regression analysis showed that with the decrease of fruit intake and dietary fiber intake, the risk of future high hs CRP increased (P <0.05), and the highest intake of Q4 was the control group. Fruits Q3 group, dietary fiber intake Q2 group, fat supply than the Q1 group, the saturated fatty acid supply than the Q2 group is Q4 group the risk of future high hs CRP 1.69,1.71,0.42,0.41 times (OR value ) (P <0.05). Conclusion Increasing dietary intake of vegetables, fruits, carbohydrates and dietary fiber can decrease plasma hs CRP level, increase fruit and dietary fiber intake, control dietary total fat supply ratio, and decrease saturated fat supply ratio may reduce heart Risk of vascular disease.