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病原学一、病毒颗粒研究自1979年一些学者报告发现与本病有关的病毒样颗粒以来,1980年,Cabral 等又从慢性肝炎患者血清中查到15～25nm 直径的球颗粒和37nm 直径的双层外壳病毒样结构。Hantz 等从本病患者血清中找到直经为35～40nm 的病毒样颗粒,直径为15～25nm 的球状及丝状颗粒。Mori 发现病人血清中有直径约32nm 的六角形颗粒,内核为22nm,外包一膜,外观为二十面的对称体。1981年,McCaul 等从感染本病的黑猩猩肝窦状隙内皮细胞的细胞质中发现有类似Bradly 等描述的结晶状排列,由直径为23nm的病毒单位组成。Burk 等也从感染本病的黑猩猩肝内看到直径为22±2nm 成群的核内颗粒及胞浆内颗粒簇(37nm),后者呈高度整齐的结晶排列。Kenneth 等通过黑猩猩试验,提示一种非甲非乙型肝炎病毒可同时引起二种不同的肝组织学形态变化。
Etiology First, the virus particle research Since 1979, some scholars report found that the virus-like particles associated with the disease since Cabral found in 1980, from patients with chronic hepatitis serum 15 ~ 25nm diameter spherical particles and 37nm diameter double Layer shell virus-like structure. Hantz, etc. from the patient’s serum to find straight through the 35 ~ 40nm virus-like particles, 15 ~ 25nm diameter spherical and filamentous particles. Mori found that there was a hexagonal particle with a diameter of about 32 nm in the serum of the patient, with a core of 22 nm, which was covered by a membrane and had the appearance of a 20-sided symmetry body. In 1981, McCaul et al. Found a crystal-like arrangement similar to that described by Bradly et al. In the cytoplasm of the sinusoidal sinusoidal endothelial cells of chimpanzees infected with this disease and consisted of virus units with a diameter of 23 nm. Burk et al. Also observed intranuclear and cytoplasmic intracellular clusters (22 nm in diameter) of 22 ± 2 nm in the liver of chimpanzees infected with this disease, with a highly ordered crystal arrangement. Kenneth and other chimpanzees through experiments, suggesting that a non-non-hepatitis B virus can cause two different liver histological changes.