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[目的]观察中晚期食管癌患者三维适行放射治疗(3DCRT)疗效并对相关因素进行分析。[方法]收集2010年1月~2011年12月我院130例食管癌患者临床资料,采用3DCRT技术,常规剂量分割,全组处方剂量为56~68Gy/6~7周,中位剂量64Gy。观察近期疗效、急性毒副反应及1、2、3年生存情况,并对相关因素进行分析。[结果]3DCRT食管癌的近期有效率为94.6%;其1、2、3年肿瘤局控率分别为79.2%、67.7%、53.1%;1、2、3年生存率分别为73.8%、54.6%、32.3%;仅9.2%患者发生3级以上放疗反应。[结论]3DCRT是一种高精度治疗技术,明显提高中晚期食道癌局部控制率和近期疗效,优于常规放射治疗,且不良反应发生率低。
[Objective] To observe the effect of three-dimensional adaptive radiotherapy (3DCRT) on advanced esophageal cancer and analyze the related factors. [Methods] The clinical data of 130 patients with esophageal cancer from January 2010 to December 2011 in our hospital were collected. The 3DCRT technique was used to divide the conventional prescription. The total prescribed dose was 56-68 Gy / 6-7 weeks and the median dose was 64 Gy. To observe the short-term curative effect, acute toxic and side effects and 1, 2, 3 year survival, and analyze the related factors. [Results] The effective rate of 3DCRT esophageal cancer was 94.6%. The rates of tumor control at 1, 2 and 3 years were 79.2%, 67.7% and 53.1% respectively. The 1, 2 and 3-year survival rates were 73.8% and 54.6% %, 32.3%; only 9.2% of patients with grade 3 or more radiotherapy. [Conclusion] 3DCRT is a high-precision treatment technique, which obviously improves the local control rate and short-term curative effect of advanced esophageal cancer, which is superior to conventional radiotherapy and has a low incidence of adverse reactions.