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用聚乙二醇、聚蔗糖、葡聚糖及银耳多糖对胰岛素进行化学修饰。经兔血糖测定其降血糖活性显示，４种修饰复合物可将胰岛素在体内的作用时间从通常的３～４ｈ延长到８～１２ｈ．
The insulin was chemically modified with polyethylene glycol, sucrose, dextran and Tremella Polysaccharides. The hypoglycemic activity measured by rabbit blood glucose showed that the four kinds of modified compounds can extend the action time of insulin in vivo from the usual 3 ~ 4h to 8 ~ 12h.