患者,女,38岁。1985年5月7日因感冒曾服SMZco 2片Tid半月,未出现任何反应。1周后又因感冒服SMZco 2片,次日眼结膜充血,全身出现荨麻疹伴搔痒,3天后巩膜皮肤发黄,尿呈浓茶色,大便正常。发病后无上腹疼痛、恶心、呕吐,胃纳差及乏力等症状。在当地医院查血清胆红素7.6 mg%,GPT270 IU/L(正常值120 IU/L),尿胆红质++,尿胆原阴性,血嗜酸性细胞正常。肝胆B超示:胆管细、胆 Patient, female, 38 years old. May 7, 1985 due to a cold had served SMZco Tid half a month, did not appear any reaction. One week later due to cold SMZco 2 tablets, conjunctival hyperemia the next day, systemic urticaria with itching, scleral skin yellow after 3 days, urine was dark brown, normal stool. After the onset of upper abdominal pain, nausea, vomiting, poor appetite and fatigue and other symptoms. Serum bilirubin 7.6 mg%, GPT270 IU / L (normal 120 IU / L), urinary bilirubin ++, urinary gallbladder negative, and blood eosinophilia were examined at a local hospital. Hepatobiliary B ultrasound shows: thin bile duct, gallbladder