结直肠癌是常见的消化道恶性肿瘤,目前治疗以外科手术为主,辅以放、化疗,术后5年生存率在50%左右。肿瘤基因治疗发展迅速,作为一种新的辅助治疗手段有重要意义。结直肠癌中研究比较多的是免疫基因治疗、自杀基因治疗、抑癌基因的应用等。基因疗法可以有效地杀伤肿瘤细胞,联合传统治疗方法可延长结直肠癌患者的生存时间,提高生活质量。 Colorectal cancer is a common gastrointestinal cancer, the current surgical treatment based, supplemented by radiotherapy and chemotherapy, postoperative 5-year survival rate of about 50%. The rapid development of tumor gene therapy, as a new means of adjuvant therapy is of great significance. Colorectal cancer research is more immune gene therapy, suicide gene therapy, tumor suppressor gene applications. Gene therapy can effectively kill tumor cells, combined with traditional therapies can extend the survival time of patients with colorectal cancer, improve quality of life.