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目的：观察硝酸异山梨酯缓释片治疗不稳定型心绞痛的临床疗效。方法将90例不稳定型心绞痛患者随机分为两组，每组45例，均予以阿司匹林、β‐受体阻滞剂、钙离子拮抗剂、他汀类药物治疗，在此基础上研究组予以硝酸异山梨酯缓释片治疗，对照组予以硝酸异山梨酯治疗，观察14 d 。统计两组临床疗效及不良反应发生状况。结果治疗14 d 末，研究组总有效率为91．1％，对照组为80．0％，研究组高于对照组但差异无显著性（P＞0．05）；两组不良反应均较轻微，研究组主要表现为头痛、面红、反射性心动过速，对照组主要表现为面红、血管扩张性头痛、反射性心动过速。结论硝酸异山梨酯缓释片治疗不稳定型心绞痛疗效显著，安全性高。“,”Objective To observe the efficacy of isosorbide dinitrate sustained‐release tablets (IDSRT) in the treatment of unstable angina pectoris (UAP) .Methods Ninety UAP patients were ran‐domly divided into 2 groups of 45 ones each .Both groups received aspirin ,β‐receptor blocking agent and statins treatment ,research group was plus IDSRT for 14 days .Efficacies and adverse reactions of both groups were added up .Results After 14 day treatment total effective rate was respectively 91 .1% in research and 80 .0% in control group ,the former was higher than the latter ,and difference wasn’t significant (P> 0 .05) .Adverse reactions of both groups were mild ,mainly headache ,flushing and reflex tachycardia in research ,and flushing ,vascular dilata‐tion headache and reflex tachycardia in control group .Conclusion IDSRT has an evident effect and higher safety in the treatment of unstable angina pectoris .