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目的研究尿毒症继发重症甲状旁腺功能亢进症(secondary hyperparathyroidism,SHPT)患者肺功能损害特征及其可能的相关因素。方法应用肺功能仪检测40例重症SHPT患者的肺功能,30例同期不伴有严重SHPT的维持性血透(maintenance hemodialysis,MHD)患者及30例健康体检者作为对照组,并就SHPT组肺功能指标与全段甲状旁腺激素(intact parathyroid hormone,iPTH)等临床检验指标做相关性分析。结果 SHPT组和MHD组较健康体检者、SHPT组较MHD组肺功能均明显下降(P<0.05)。SHPT组患者肺功能多项指标与血iPTH、C反应蛋白(C reactive protein,CRP)、透析龄(dialysis age)呈负相关(P<0.05),与血红蛋白(hemoglobin,Hb)、白蛋白(albumin,Alb)呈正相关(P<0.05)。结论重症SHPT患者肺功能明显异常。血iPTH、透析龄、血红蛋白、白蛋白及CRP可能是影响SHPT患者肺功能的重要因素。
Objective To study the characteristics of pulmonary dysfunction in patients with secondary hyperparathyroidism (SHPT) secondary to uremia and its possible related factors. Methods Pulmonary function tests were performed in 40 severe SHPT patients. Thirty patients with maintenance hemodialysis (MHD) without severe SHPT and 30 healthy controls were enrolled as control group. The lung function of SHPT group The correlation between functional indexes and clinical test indexes such as intact parathyroid hormone (iPTH) was analyzed. Results The pulmonary function of SHPT group and MHD group was significantly lower than that of healthy subjects and SHPT group (P <0.05). Many indexes of pulmonary function in SHPT group were negatively correlated with iPTH, C reactive protein (CRP) and dialysis age (P <0.05), but not with hemoglobin (Hb), albumin , Alb) (P <0.05). Conclusions Patients with severe SHPT have abnormal lung function. Blood iPTH, dialysis age, hemoglobin, albumin and CRP may be important factors that affect lung function in SHPT patients.