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本文详细地研究了用巯基络合剂治疗,110名由于局部振动所致振动病的疗效。50名振动病患者作对照组。按Ⅱpora~raHa分类,诊断为Ⅰ期振动病75名,Ⅱ期振动病85名。 将所有病人分成三组(临床表现及职业成分相似):第一组50例采用一般综合治疗(解痉素、普鲁卡因、维生素B族和C、血管扩张药物、理疗)。第二组50例单用巯基络合剂治疗,其中30例用5％二巯基丙磺酸钠5毫升溶液,每天肌注一次,治疗2～3周;20例用D—青霉胺150毫克,一日四次饭后口服,治疗3～4周。第三组60例,采用一般综合治疗配合二巯基丙磺酸钠治疗。 经治疗后,一般来讲,所有三组病人的临床症状都得到改善:肢体感觉异常及疼痛、发绀、掌心多汗及低温的症状减轻或消失,厥冷性的肢端血管痉挛变稀少或消失。神经血管系统的症状得到很好改善。
This article details the treatment with thiol complexing agent, 110 due to local vibration-induced vibration disease. 50 patients with vibration sickness as a control group. According to Ⅱ pora ~ raHa classification, diagnosed as stage I disease 75, stage II vibration 85. All patients were divided into three groups (similar in clinical presentation and occupational composition): The first group of 50 patients received general treatment (spasmodic, procaine, vitamin B and C, vasodilators, physiotherapy). The second group of 50 patients treated with sulfhydryl complex alone, of which 30 cases with 5% sodium dimercaptopropane sulfonate solution, once a day intramuscularly for 2 to 3 weeks; 20 cases with D-penicillamine 150 mg , Four times a day orally after oral administration, treatment of 3 to 4 weeks. The third group of 60 cases, the general treatment with sodium dimercaptopropane sulfonate treatment. After treatment, in general, clinical symptoms were improved in all three groups: sensory abnormalities and pain in limbs, cyanosis, palpation of sweat and symptoms of hypothermia relieved or disappeared, vomiting exacerbation of vasospasm diminished or disappeared . The symptoms of the neurovascular system are well improved.