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In clinical research,our aim is to design a study which would be able to derive a valid and meaningful scientific conclusion using appropriate statistical methods.The conclusions derived from a research study can either improve health care or result in inadvertent harm to patients.Hence,this requires a well-designed clinical research study that rests on a strong foundation of a detailed methodology and goved by ethical clinical principles.The purpose of this review is to provide the readers an overview of the basic study designs and its applicability in clinical research.