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为闡明吐酒石心肌中毒时代謝与机能障碍的关系,研究了急性中毒早期狗心血流动力和心肌利用糖类能源的变化。狗12只,按Fick原理測心輸出量,用冠状窦插管法研究冠脉流量和心肌代謝。采用配对实驗,每狗实驗2次,观察对照期和肺动脉內注射吐酒石10毫克/公斤后变化。实驗結果作t测驗个别比較和组間比較以排除吐酒石外的影响因素。对照期1°时心脏血流动力变化不显著,但动靜脉中乳酸、丙酮酸增高,心肌耗氧量、丙酮酸消耗量增加。4°时主动脉压、总外周阻力和肺血管阻力增高,心脏指数与左右心室作功量减少。这些可能主要是戊巴比妥鈉的作用。吐酒石后1°,左右心室作功量不增加,而动靜脉中糖、乳酸、丙酮酸增加,乳酸的动靜脉差和心肌消耗量增加,糖类在心肌內氧化时所消耗氧量占心肌耗氧总量的％增加。因作功不增而耗能增加,故左室功率降低。吐酒石后4°主动脉压、肺动脉压、左右心室作功量及冠脉流量均减少,而心肌耗能量不减少,故左室功率也减少。結果說明吐酒石損害心肌机能与心肌代謝紊乱有关。但心肌仍能按比例提取糖类能源,且心肌无氧代謝％不增,說明心肌有氧代謝(能量釋放)无障碍。推測心功率降低可能是干扰了氧化磷酸化反应(能量貯存)或能量轉换(能量利用)的結果。吐酒石急性中毒早期,血中糖、乳酸、丙酮酸相应升高,提示全身无氧糖酵解加强。
In order to elucidate the relationship between metabolism and dysfunction in tattlermyocardial poisoning, the changes of dog blood flow velocity and carbohydrate energy in early stage of acute poisoning were studied. 12 dogs, measured by Fick principle of cardiac output, coronary sinus intubation with coronary flow and myocardial metabolism. Using paired experiments, two experiments per dog, the control period and pulmonary arterial injection of tartar 10 mg / kg change. Experimental results for t test individual comparison and comparison between groups to rule out the factors outside the spit tartar. The control group 1 ° change in cardiac hemodynamics was not significant, but the arterial and venous lactic acid, pyruvate increased myocardial oxygen consumption, pyruvate consumption increased. 4 ° aortic pressure, total peripheral resistance and pulmonary vascular resistance increased cardiac index and left ventricular reduction of work capacity. These may mainly be the effects of sodium pentobarbital. 1 ° after spit tartar, left and right ventricular work capacity does not increase, while the arteriovenous in the sugar, lactate, pyruvate increased lactic acid arteriovenous and myocardial consumption increased, carbohydrate consumption in the myocardial oxygen consumption account for Myocardial oxygen consumption increased the total%. Because work does not increase and energy consumption increases, so reduce the left ventricular power. 4 ° spit tartar aortic pressure, pulmonary arterial pressure, left and right ventricular work capacity and coronary flow were reduced, and myocardial energy consumption is not reduced, so the left ventricular power is also reduced. The results showed that spit tartal damage myocardial function and myocardial metabolic disorders. However, myocardial energy is still in proportion to extract carbohydrates, and myocardial oxygen metabolism% does not increase, indicating myocardial oxygen metabolism (energy release) barrier-free. It is hypothesized that a decrease in cardiac power may be the result of interfering with the oxidative phosphorylation (energy storage) or energy conversion (energy utilization). Tuba wine acute poisoning early, blood sugar, lactate, pyruvate corresponding increase, suggesting that systemic anaerobic glycolysis to strengthen.