高血糖、细胞代谢紊乱是糖尿病导致组织器官损伤的一个基本病理生理改变,而上述过程的启动因素是细胞内糖摄入过多。尽管严格控制血糖能够明显减少糖尿病肾病(ＤＮ)的发生和延缓ＤＮ的进展,但在一些长期血糖控制良好的患者中同样能够发生ＤＮ[1,2]。上述现象表明,除了细胞外高 Hyperglycemia, metabolic disorders of cells is a basic pathophysiological change of tissue and organ damage caused by diabetes, and the initiating factor of the above process is excessive intracellular sugar intake. Although strict control of blood glucose can significantly reduce the incidence of diabetic nephropathy (DN) and delay the progression of DN, DN can also occur in some patients with well-controlled glycemia for long periods [1,2]. The above phenomenon shows that, in addition to extracellular high