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目的：研究大鼠加速性弥慢性脑损伤合并低血压及脑缺血、缺氧时，颅内压（ＩＣＰ）及脑灌注压（ＣＰＰ）变化与双阿斯匹林联偶血红蛋白液（ＤＣＬＨｂ）治疗作用。方法：２４只ＳＤ大鼠随机分为假手术对照、脑损伤并低血压与脑缺血及治疗三组。采用Ｍａｒｍａｒｏｕ大鼠加速性弥慢性脑损伤模型，抽血及颈动脉结扎造成低血压及脑缺血、缺氧。所有动物均气管内插管并实施同步生理监护。结果：伤后４小时，与假手术组对比，合并低血压与脑缺血组出现ＩＣＰ增高及ＣＰＰ降低（Ｐ＜０．０５），ＤＣＬＨｂ治疗组二者接近正常。结论：合并低血压与脑缺血组出现ＩＣＰ增高及ＣＰＰ降低提示低血压或脑缺血参予脑损害的加重过程，ＤＣＬＨｂ则可能通过提高ＣＰＰ发挥脑保护作用。
Objective: To investigate the changes of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with accelerated diffuse brain injury associated with hypotension and cerebral ischemia and hypoxia, Therapeutic effect. Methods: Twenty-four SD rats were randomly divided into three groups: sham operation control, brain injury, hypotension and cerebral ischemia. Marmarou rats with accelerated amebic brain injury model, blood and carotid artery ligation caused by hypotension and cerebral ischemia, hypoxia. All animals received endotracheal intubation and synchronized physiologic monitoring. Results: At 4 hours after injury, compared with the sham-operation group, ICP increased and CPP decreased (P <0.05) in both hypotension and cerebral ischemia groups, and the two groups were close to normal in DCLHb treatment group. CONCLUSIONS: Hypocholesterolemia and cerebral ischemia with increased ICP and decreased CPP suggest that hypotension or cerebral ischemia may participate in the process of aggravating brain damage. DCLHb may exert cerebral protection by increasing CPP.