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目的:探讨ARB治疗充血性心力衰竭(CHF)时对脑钠肽(BNP)的影响。方法:76例CHF患者分为常规治疗组和坎地沙坦组,测定治疗前后BNP水平,以核素心室显像测定LVEF及LVEDD。结果:CHF患者BNP较正常组升高且在心功能分级间有统计学差异,坎地沙坦组BNP水平较常规组下降明显。结论:ARB能抑制CHF患者RAA S系统功能亢进。
Objective: To investigate the effect of ARB on brain natriuretic peptide (BNP) in patients with congestive heart failure (CHF). Methods: 76 CHF patients were divided into routine treatment group and candesartan group. BNP levels were measured before and after treatment. LVEF and LVEDD were measured by radionuclide ventriculography. Results: BNP levels in patients with CHF were significantly higher than those in normal controls and there was a significant difference in cardiac function scores. BNP levels in candesartan group were significantly lower than those in normal patients. Conclusion: ARB can inhibit the hyperactivity of RAA S system in CHF patients.