论文部分内容阅读
目的 :观察国产紫杉醇联合顺铂治疗晚期肺癌 18例的疗效及毒副反应。方法 :第 1天紫杉醇135mg/m2 ,静滴 3h ,第 1～ 4天用顺铂 2 5mg/m2 ,4周为 1个周期 ,3个周期为 1个疗程 ,1个疗程后评价其疗效及毒副反应。结果 :18例中 2例完全缓解 ,6例部分缓解 ,8例稳定 ,2例进展 ,总有效率 44 4% ;紫杉醇的主要毒副反应为粒细胞减少、肌肉疼痛、胃肠道反应及脱发 ,毒性反应程度大多在Ⅰ～Ⅱ度。结论 :紫杉醇是治疗晚期肺癌的有效药物
Objective: To observe the efficacy and side effects of domestic paclitaxel combined with cisplatin in the treatment of advanced lung cancer in 18 cases. Methods: The first day paclitaxel 135mg / m2, intravenous infusion 3h, the first 4 days with cisplatin 25mg / m2, 4 weeks for a cycle, 3 cycles for a course of treatment, after a course of evaluation of its efficacy and Toxic reaction. Results: Two of 18 patients were completely relieved, 6 were partially relieved, 8 were stable, 2 were progressive and the total effective rate was 44.4%. The main side effects of paclitaxel were neutropenia, muscle pain, gastrointestinal reaction and alopecia , The degree of toxicity is mostly in Ⅰ ~ Ⅱ degree. Conclusion: Paclitaxel is an effective drug for the treatment of advanced lung cancer